PARA-HYDROGEN GENERATORS

Featuring Closed Cycle and Flow Cryostats

JOIN THE FUTURE OF HYPERPOLARIZATION IMAGING

-Inexpensive - Fast - Simple - Reliable - Reproducible-

Para-hydrogen generators employ cryogenic temperatures, where paramagnetic catalyst (iron oxide) converts normal dihydrogen gas into para-hydrogen-enriched gas. Normal dihydrogen gas consists of 25% para-hydrogen and 75% ortho-hydrogen. The percentage enrichment is temperature dependent ranging from 50% Enrichment at 77K and >99% Enrichment at 10K.

 

 

The inherently long lived singlet spin state of Para-Hydrogen can be used for Magnetic Resonance (MR) hyperpolarization techniques such as; (1) Para-Hydrogen Induced Polarization (PHIP), (2) Signal Amplification by Reversible Exchange (SABRE), and (3) Para-Hydrogen and Synthesis Allow Dramatically Enhanced Nuclear Spin Amplification (PASADENA). These techniques significantly enhance MR sensitivity by orders of magnitude by increasing nuclear spin polarization, thus enabling functional and metabolic molecular imaging, and other biomedical applications.

XeUS Technologies offers 2 Options to meet your Para-Hydrogen Needs and can be paired with our Hyperpolarized Propane Generator:

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OPTION 1 Flow Cryostat:

Liquid Nitrogen Para-Hydrogen Generator

Price: €2,970

Up to 50% Para-Hydrogen Enrichment

  • Designed to be submerged in a liquid Nitrogen.

  • Copper Wound Para-Hydrogen Converter packed with Iron Oxide Catalyst. 

  • Operated with Ultra High Purity Hydrogen Gas (>99.999%).

  • Operating Pressure: Up to 500 PSI

  • Flow Rate: Up to 20 Standard Liters Per Minute

A previous generation generator model has been employed in a number of previously published studies cited below.

Operating Manual:

REFERENCES / CITED WORK:

1) Barskiy, D. A.; Salnikov, O. G.; Shchepin, R. V.; Feldman, M. A.; Coffey, A. M.; Kovtunov, K. V.; Koptyug, I. V.; Chekmenev, E. Y. J. Phys. Chem. C 2016, 120, 29098.

https://pubs.acs.org/doi/10.1021/acs.jpcc.6b07555

2) Barskiy, D. A.; Shchepin, R. V.; Coffey, A. M.; Theis, T.; Warren, W. S.; Goodson, B. M.; Chekmenev, E. Y. J. Am. Chem. Soc. 2016, 138, 8080.

https://pubs.acs.org/doi/10.1021/jacs.6b04784

3) Shchepin, R. V.; Barskiy, D. A.; Coffey, A. M.; Theis, T.; Shi, F.; Warren, W. S.; Goodson, B. M.; Chekmenev, E. Y. ACS Sensors 2016, 1, 640.

https://pubs.acs.org/doi/10.1021/acssensors.6b00231

The perfect entry level Para-Hydrogen Generator to get you quickly started.

We accept request for custom setups to help with your application or to mate this equipment to your current setup, such as a gas-manifolds etc. 

OPTION 2 Closed Cycle:

Advanced Research Systems (ARS) Closed Cycle Cryostat Para-Hydrogen Generator

700PSI System + Stand HiRes.jpg

> 99% Para-Hydrogen Enrichment.

  • Crysostat cooling in 2 stages.

  • Catalytic Chamber packed with Iron Oxide or Charcoal Catalyst. 

  • Operated with Ultra High Purity Hydrogen Gas (>99.999%).

  • Operating Pressure: Up to 500 -750 PSI

  • Flow Rate: Up to 4 Standard Liters Per Minute

  • Different Configurations and Equipment Options Available.

  • Robust and User Friendly Operation. Can Operate in any orientation.

  • Consumable Cost Efficiency enabled by closed cycle operation of Liquid Helium. 

This generator model has been employed in a number of previously published studies cited below.

REFERENCES / CITED WORK:

1)Benjamin Chapman, Baptiste Joalland, Collier Meersman, Jessica Ettedgui, Rolf E Swenson, Murali C Krishna, Panayiotis Nikolaou, Kirill V Kovtunov, Oleg G Salnikov, Igor V Koptyug, Max E Gemeinhardt, Boyd M Goodson, Roman V Shchepin, Eduard Y Chekmenev. Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K. 2021, 93 (24), 8476-8483

Link:https://doi.org/10.1021/acs.analchem.1c00716

2)Baptiste Joalland, Shiraz Nantogma, Md Raduanul Chowdhury, Panayiotis Nikolaou, Eduard Y Chekmenev. Magnetic shielding of parahydrogen hyperpolarization experiments for the masses. 2021

Link:https://doi.org/10.1002/mrc.5167

3)Oleg G Salnikov, Panayiotis Nikolaou, Nuwandi M Ariyasingha, Kirill V Kovtunov, Igor V Koptyug, Eduard Y Chekmenev. Clinical-scale batch-mode production of hyperpolarized propane gas for MRI. 2019, 91 (7), 4741-4746

Link:https://doi.org/10.1021/acs.analchem.9b00259

4)Oleg G Salnikov, Kirill V Kovtunov, Panayiotis Nikolaou, Larisa M Kovtunova, Valerii I Bukhtiyarov, Igor V Koptyug, Eduard Y Chekmenev. Cover Feature: Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane (ChemPhysChem 20/2018). 2018, 19 (20), 2599-2599

Link:https://doi.org/10.1002/cphc.201800842

5)Oleg G Salnikov, Kirill V Kovtunov, Panayiotis Nikolaou, Larisa M Kovtunova, Valerii I Bukhtiyarov, Igor V Koptyug, Eduard Y Chekmenev. Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane. 2018, 19 (20), 2621-2626

Link:https://doi.org/10.1002/cphc.201800690

6) Coffey, A. M.; Shchepin, R. V.; Truong, M. L.; Wilkens, K.; Pham, W.; Chekmenev, E. Y. Anal. Chem. 2016, 88, 8279. https://pubs.acs.org/doi/10.1021/acs.analchem.6b02130

7) Truong, M. L.; Theis, T.; Coffey, A. M.; Shchepin, R. V.; Waddell, K. W.; Shi, F.; Goodson, B. M.; Warren, W. S.; Chekmenev, E. Y. J. Phys. Chem. C 2015, 119, 8786.

https://pubs.acs.org/doi/10.1021/acs.jpcc.5b01799

8) Waddell, K. W.; Coffey, A. M.; Chekmenev, E. Y. J. Am. Chem. Soc. 2011, 133, 97.

https://pubs.acs.org/doi/10.1021/ja108529m

9) Barskiy, D. A.; Kovtunov, K. V.; Koptyug, I. V.; He, P.; Groome, K. A.; Best, Q. A.; Shi, F.; Goodson, B. M.; Shchepin, R. V.; Coffey, A. M.; Waddell, K. W.; Chekmenev, E. Y. J. Am. Chem. Soc. 2014, 136, 3322.

https://pubs.acs.org/doi/10.1021/ja501052p

10) Feng, B.; Coffey, A. M.; Colon, R. D.; Chekmenev, E. Y.; Waddell, K. W. J. Magn. Reson. 2012, 214, 258.

https://www.sciencedirect.com/science/article/abs/pii/S1090780711004836?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268554/

11) Theis, T.; Truong, M. L.; Coffey, A. M.; Shchepin, R. V.; Waddell, K. W.; Shi, F.; Goodson, B. M.; Warren, W. S.; Chekmenev, E. Y. J. Am. Chem. Soc. 2015, 137, 1404.

https://pubs.acs.org/doi/10.1021/ja512242d

This advanced Para-Hydrogen Generator will meet all your needs ranging from high-resolution NMR studies all the way to clinical trials.

We accept request for custom setups to help with your application or to mate this equipment to your current setup, such as a gas-manifolds etc. 

Price: Contact Us for a Quote

Data Sheet

Operations Manual

Technical Manual