Xenon Hyperpolarizer

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Option 1: 

World-wide: €329,000*

North America: $319,000*

  • Fully Automated Device with Graphical User Interface (Laptop Required)

  • In-Situ NMR Polarimitry Included

Option 2:

World-wide: €309,000*

North America: $299,000*

  • Manual Device with Switch Board Operation

  • In-Situ NMR Polarimitry

*Pricing Already Includes Academic Discount and On-Site Installation and Training.

Pricing

The XeUS Xenon Polarizer is a Fully Automated Device for NMR Hyperpolarization of Xe-129 gas:

  • Pre-Mixed (Xe:N2) Gas Inlet

  • Up to 90% Nuclear Spin Polarization with 15% Xenon Mix

  • Up to 60% Nuclear Spin Polarization with 50% Xenon Mix

  • Small footprint: 1.2 m (w) x 1.5 m (h) x 0.6 m (d)

  • No Cryogens Collection required for operation

  • Production yield: 1L/cycle, ~2 Cycles/Hr

  • In Situ NMR Polarimity for Quality Assurance

  • Batch Mode / Stopped Flow Operation

  • Aluminum SEOP Cell Heating Jacket - Fast Cool Down and HPXe Gas Transfer

  • On Board Laser Retro-Reflection for 20% Increased Polarization

  • Wireless Connection to the Polarizer with Graphical User Interface

Disclaimer

The long-term goal of XeUS Technologies is to develop and provide a clinically approved xenon-129 hyperpolarizer for pulmonary imaging and beyond. Our currently-offered Xenon-129 hyperpolarizer is only for research-use onlyi.e. no clearance has been received from the corresponding government regulatory agencies although we do not restrict our customers from seeking regulatory approvals for use in humans (e.g. US IND) on their own or with our help.

REFERENCE / CITED WORK:

1) Jonathan R. Birchall, Md Raduanul H. Chowdhury, Panayiotis Nikolaou ,Yuri A. Chekmenev, Anton Shcherbakov, Michael J. Barlow, Boyd M. Goodson, Eduard Y. Chekmenev. Pilot Quality-Assurance Study of a Third-Generation Batch-Mode Clinical-Scale Automated Xenon-129 Hyperpolarizer. Molecules 2022, 27,1327

Link: https://doi.org/10.3390/molecules27041327

2)Alixander S Khan, Rebecca L Harvey, Jonathan R Birchall, Robert K Irwin, Panayiotis Nikolaou, Geoffry Schrank, Kiarash Emami, Andrew Dummer, Michael J Barlow, Boyd M Goodson, Eduard Y Chekmenev. Enabling Clinical Technologies for Hyperpolarized 129Xenon Magnetic Resonance Imaging and Spectroscopy. 2021, 93 (24), 8476-8483

Link:https://doi.org/10.1002/ange.202015200

3)Alixander S Khan, Rebecca L Harvey, Jonathan R Birchall, Robert K Irwin, Panayiotis Nikolaou, Geoffry Schrank, Kiarash Emami, Andrew Dummer, Michael J Barlow, Boyd M Goodson, Eduard Y Chekmenev. Enabling Clinical Technologies for Hyperpolarized Xenon-129 MRI and Spectroscopy. 2021, 60(41):22126-22147

Link:10.1002/anie.202015200

4)Jonathan R Birchall, Robert K Irwin, Md Raduanul H Chowdhury, Panayiotis Nikolaou, Boyd M Goodson, Michael J Barlow, Anton Shcherbakov, Eduard Y Chekmenev. Automated Low-Cost In Situ IR and NMR Spectroscopy Characterization of Clinical-Scale 129Xe Spin-Exchange Optical Pumping. 2021, 93 (8) 3883-3888

Link:https://doi.org/10.1021/acs.analchem.0c04545

5)Jonathan R Birchall, Robert K Irwin, Panayiotis Nikolaou, Aaron M Coffey, Bryce E Kidd, Megan Murphy, Michael Molway, Liana B Bales, Kaili Ranta, Michael J Barlow, Boyd M Goodson, Matthew S Rosen, Eduard Y Chekmenev. XeUS: A second-generation automated open-source batch-mode clinical-scale hyperpolarizer. 2020, 319, 106813

Link:https://doi.org/10.1016/j.jmr.2020.106813

6)Jonathan R Birchall, Robert K Irwin, Panayiotis Nikolaou, Ekaterina V Pokochueva, Kirill V Kovtunov, Igor V Koptyug, Michael J Barlow, Boyd M Goodson, Eduard Y Chekmenev. Pilot multi-site quality assurance study of batch-mode clinical-scale automated xenon-129 hyperpolarizers. 2020, 316, 106755

Link:https://doi.org/10.1016/j.jmr.2020.106755

7)Jonathan R Birchall, Panayiotis Nikolaou, Robert K Irwin, Michael J Barlow, Kaili Ranta, Aaron M Coffey, Boyd M Goodson, Ekaterina V Pokochueva, Kirill V Kovtunov, Igor V Koptyug, Eduard Y Chekmenev. Helium-rich mixtures for improved batch-mode clinical-scale spin-exchange optical pumping of Xenon-129. 2020, 315, 106739

Link:https://doi.org/10.1016/j.jmr.2020.106739

8)Jason G Skinner, Kaili Ranta, Nicholas Whiting, Aaron M Coffey, Panayiotis Nikolaou, Matthew S Rosen, Eduard Y Chekmenev, Peter G Morris, Michael J Barlow, Boyd M Goodson. High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments. 2020, 312, 106686

Link:https://doi.org/10.1016/j.jmr.2020.106686

9) Jonathan R Birchall, Panayiotis Nikolaou, Aaron M Coffey, Bryce E Kidd, Megan Murphy, Michael Molway, Liana B Bales, Boyd M Goodson, Robert K Irwin, Michael J Barlow, Eduard Y Chekmenev. Batch-mode clinical-scale optical hyperpolarization of Xenon-129 using an aluminum jacket with rapid temperature ramping. 2020, 92 (6) 4309-4316

Link: https://doi.org/10.1021/acs.analchem.9b05051

10) Nikolaou, P.; Coffey, A. M.; Walkup, L. L.; Gust, B. M.; Whiting, N. R.; Newton, H.; Muradyan, I.; Dabaghyan, M.; Ranta, K.; Moroz, G.; Patz, S.; Rosen, M. S.; Barlow, M. J.; Chekmenev, E. Y.; Goodson, B. M. Near-Unity nuclear polarization with an open-source 129Xe hyperpolarizer for NMR and MRI. 2013 110 (35) 14150-14155.

Link: https://doi.org/10.1073/pnas.1306586110

11) Barskiy, D. A.; Coffey, A. M.; Nikolaou, P.; Mikhaylov, D. M.; Goodson, B. M.; Branca, R. T.; Lu, G. J.; Shapiro, M. G.; Telkki, V.-V.; Zhivonitko, V. V.; Koptyug, I. V.; Salnikov, O. G.; Kovtunov, K. V.; Bukhtiyarov, V. I.; Rosen, M. S.; Barlow, M. J.; Safavi, S.; Hall, I. P.; Schröder, L.; Chekmenev, E. Y. Nmr Hyperpolarization Techniques of Gases. Chem. Eur. J. 2017, 23, 725–751.

Link: https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201603884

12) Nikolaou, P.; Coffey, A. M.; Walkup, L. L.; Gust, B. M.; Whiting, N. R.; Newton, H.; Muradyan, I.; Dabaghyan, M.; Ranta, K.; Moroz, G.; Patz, S.; Rosen, M. S.; Barlow, M. J.; Chekmenev, E. Y.; Goodson, B. M. Xena: An Automated 'Open-Source' 129xe Hyperpolarizer for Clinical Use. Magn. Reson. Imaging 2014, 32, 541-550.

Link: https://www.sciencedirect.com/science/article/pii/S0730725X14000459

13) Nikolaou, P.; Coffey, A. M.; Walkup, L. L.; Gust, B.; LaPierre, C.; Koehnemann, E.; Barlow, M. J.; Rosen, M. S.; Goodson, B. M.; Chekmenev, E. Y. A 3d-Printed High Power Nuclear Spin Polarizer. J. Am. Chem. Soc. 2014, 136 1636–1642.

Link: https://pubs.acs.org/doi/abs/10.1021/ja412093d

14) Nikolaou, P.; Coffey, A. M.; Ranta, K.; Walkup, L. L.; Gust, B.; Barlow, M. J.; Rosen, M. S.; Goodson, B. M.; Chekmenev, E. Y. Multi-Dimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode 129xe Hyperpolarizers. J. Phys. Chem. B 2014, 118, 4809–4816.

Link https://pubs.acs.org/doi/abs/10.1021/jp501493k

15) Nikolaou, P.; Coffey, A. M.; Barlow, M. J.; Rosen, M.; Goodson, B. M.; Chekmenev, E. Y. Temperature-Ramped 129xe Spin Exchange Optical Pumping. Anal. Chem. 2014, 86, 8206–8212.

Link: https://pubs.acs.org/doi/10.1021/ac501537w

16) Nikolaou, P.; Coffey, A. M.; Walkup, L. L.; Gust, B. M.; Whiting, N.; Newton, H.; Barcus, S.; Muradyan, I.; Dabaghyan, M.; Moroz, G. D.; Rosen, M.; Patz, S.; Barlow, M. J.; Chekmenev, E. Y.; Goodson, B. M. Near-Unity Nuclear Polarization with an 'Open-Source' 129xe Hyperpolarizer for Nmr and Mri. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 14150-14155.

Link: https://www.pnas.org/content/110/35/14150.long

17) Whiting, N.; Nikolaou, P.; Eschmann, N. A.; Barlow, M. J.; Lammert, R.; Ungar, J.; Hu, W.; Vaissie, L.; Goodson, B. M. Using Frequency-Narrowed, Tunable Laser Diode Arrays with Integrated Volume Holographic Gratings for Spin-Exchange Optical Pumping at High Resonant Fluxes and Xenon Densities. Appl. Phys. B-Lasers Opt. 2012, 106, 775-788.

Link: https://link.springer.com/article/10.1007/s00340-012-4924-x

18)Nikolaou, P.; Whiting, N.; Eschmann, N. A.; Chaffee, K. E.; Goodson, B. M. Generation of Laser-Polarized Xenon Using Fiber-Coupled Laser-Diode Arrays Narrowed with Integrated Volume Holographic Gratings. J. Magn. Reson. 2009, 197, 249-254.

Link: https://www.sciencedirect.com/science/article/pii/S1090780708004217